The story of a cortex cell atlas, developed in Africa, now published in Nature Genetics.

28 Nov 2024 | By Hayley Tomes
nature genetics
28 Nov 2024 | By Hayley Tomes

Dr Dorit Hockman, NI researcher in the division of Cell Biology, and team have just published a paper in Nature Genetics entitled: A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation.

It formed part of a collection of more than 40 peer-reviewed papers published in Nature and other Nature Portfolio journals as part of the Human Cell Atlas (HCA). Researchers with the global HCA consortium report significant progress in their quest for a better understanding of the cells of the human body in health and disease.

They are making truly notable strides in their mission, particularly in three major aspects: mapping individual adult tissues or organs; mapping developing human tissues; and developing groundbreaking new analytical methods, including artificial intelligence / machine learning based methods.

Find the paper here, and read more about this latest HCA success here

Congrats to all the NI members and students who were involved in bringing these important discoveries to print: Christina Steyn, Ruvimbo Mishi, Stephanie Fillmore, Dr Thijs Verhoog, A/Prof Ursula Rohlwink, Dr Nico Enslin, Prof Muazzam Jacobs, A/Prof Joseph Raimondo, Prof Anthony Figaji and of course Dr Dorit Hockman!

nature genetics
Data you need to be a geneticist to understand but which shows the sheer scale of data in this work. It also compares genetic markers between paediatric and adult datasets which highlights how gene expression dynamics change during human brain maturation.